Urological Science
Volume 21, Issue 4 , Pages 163-168, December 2010

Effect of Alcohol Consumption on the Risk of Erectile Dysfunction

  • Bang-Ping Jiann

      Affiliations

    • Corresponding Author InformationCorresponding author. Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, 386, Ta-Chung 1st Road, Kaohsiung, Taiwan

Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

Received 20 November 2009

Article Outline

Alcohol consumption is a common behavior in social circumstances worldwide. Epidemiological studies have suggested that moderate alcohol consumption reduces cardiovascular morbidity and mortality. The cardiovascular protective effects of alcohol may be attributed to its antioxidant, vasorelaxant, and antithrombotic properties, elevation of high-density lipoprotein or increase of nitric oxide production. Erectile dysfunction (ED) is a harbinger of cardiovascular diseases. Most epidemiological studies have also found that alcohol consumption, like its relationship with coronary artery disease, is related to ED in a J-shaped manner, with moderate consumption conferring the highest protection and higher consumption less benefits. In epidemio-logical studies, it is difficult to distinguish the ethanol effects from those of associated confounding factors. Meanwhile, long-term alcohol users, especially in those with alcohol liver disease, are highly associated with ED. More research is needed to investigate the true effects of alcohol consumption on cardiovascular diseases or ED.

Key Words:  alcohol , coronary artery disease , erectile dysfunction , mortality

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References 

  1. Fernandez-Sola J , Estruch R , Grau JM , Pare JC , Rubin E , Urbano-Marquez A . The relation of alcoholic myopathy to cardiomyopathy . Ann Intern Med . 1994;120:529–536
  2. Kannel WB , Ellison RC . Alcohol and coronary heart disease: the evidence for a protective effect . Clin Chim Acta . 1996;246:59–76
  3. Iacoviello L , de Gaetano G . Alcohol and cardiovascular diseases. Current knowledge and controversies . Recenti Prog Med . 2003;94:451–455
  4. Thompson IM , Tangen CM , Goodman PJ , Probstfield JL , Moinpour CM , Coltman CA . Erectile dysfunction and subsequent cardiovascular disease . JAMA . 2005;294:2996–3002
  5. Schwartz BG , Kloner RA . How to save a life during a clinic visit for erectile dysfunction by modifying cardiovascular risk factors . Int J Impot Res . 2009;21:327–335
  6. Lue TF . Erectile dysfunction . N Engl J Med . 2000;342:1802–1813
  7. National Health and Medical Research Council  . In: Australian Guidelines to Reduce Health Risks from Drinking Alcohol . Canberra, Australia: National Health and Medical Research Council; 2009;p. 1–181
  8. Jacobs MR , Fehr KOB . Drugs and Drug Abuse: A Reference Text . 2nd ed.. Toronto: Addiction Research Foundation; 1987;
  9. Edenberg HJ . The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants . Alcohol Res Health . 2007;30:5–13
  10. Grobin AC , Matthews DB , Devaud LL , Morrow AL . The role of GABA(A) receptors in the acute and chronic effects of ethanol . Psychopharmacology (Berl) . 1998;139:2–19
  11. World Health Organization  . Chapter 4: Psychopharmacology of dependence for different drug classes . In: Neuroscience of Psychoactive Substance Use and Dependence . Geneva, Switzerland: World Health Organization; 2004;p. 67–124
  12. Rivier C , Rivest S , Vale W . Alcohol-induced inhibition of LH secretion in intact and gonadectomized male and female rats: possible mechanisms . Alcohol Clin Exp Res . 1992;16:935–941
  13. Rudel LL , Leathers CW , Bond MG , Bullock BC . Dietary ethanol-induced modification in hyperlipoproteinemia and atherosclerosis in nonhuman primates (Macaca nemestrina) . Arteriosclerosis . 1981;1:144–155
  14. Barboriak JJ , Anderson AJ , Hoffmann RG . Interrelationships between coronary artery occlusion, high-density lipoprotein cholesterol, and alcohol intake . J Lab Clin Med . 1979;94:348–353
  15. Gordon T , Kannel WB . Drinking habits and cardiovascular disease: The Framingham Study . Am Heart J . 1983;105:667–673
  16. Conway DI . Alcohol consumption and the risk for disease. Is there a dose-risk relationship between alcohol and disease? . Evid Based Dent . 2005;6:76–77
  17. Maclure M . Demonstration of deductive meta-analysis: ethanol intake and risk of myocardial infarction . Epidemiol Rev . 1993;15:328–351
  18. Seigneur M , Bonnet J , Dorian B , et al.   Effect of the consumption of alcohol, white wine, and red wine on platelet function and serum lipids . J Appl Cardiol . 1990;5:215–222
  19. Klatsky AL , Friedman GD , Armstrong MA , Kipp H . Wine, liquor, beer, and mortality . Am J Epidemiol . 2003;158:585–595
  20. Gruchow HW , Hoffmann RG , Anderson AJ , Barboriak JJ . Effects of drinking patterns on the relationship between alcohol and coronary occlusion . Atherosclerosis . 1982;43:393–404
  21. Fuchs FD , Chambless LE . Is the cardioprotective effect of alcohol real? . Alcohol . 2007;41:399–402
  22. Friesema IH , Zwietering PJ , Veenstra MY , et al.   The effect of alcohol intake on cardiovascular disease and mortality disappeared after taking lifetime drinking and covariates into account . Alcohol Clin Exp Res . 2008;32:645–651
  23. Dyer AR , Stamler J , Paul O , et al.   Alcohol cardiovascular risk factors and mortality: the Chicago experience . Circulation . 1981;64(3 Pt 2):III20–III27
  24. Gaziano JM , Buring JE , Breslow JL , et al.   Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions and decreased risk of myocardial infarction . N Engl J Med . 1993;329:1829–1834
  25. Friedman GD , Klatsky AL . Is alcohol good for your health? . N Engl J Med . 1993;329:1882–1883
  26. Abou-Agag LH , Khoo NK , Binsack R , et al.   Evidence of cardiovascular protection by moderate alcohol: role of nitric oxide . Free Radic Biol Med . 2005;39:540–548
  27. Venkov CD , Myers PR , Tanner MA , Su M , Vaughan DE . Ethanol increases endothelial nitric oxide production through modulation of nitric oxide synthase expression . Thromb Haemost . 1999;81:638–642
  28. Husain K , Vazquez-Ortiz M , Lalla J . Down regulation of aortic nitric oxide and antioxidant systems in chronic alcohol-induced hypertension in rats . Hum Exp Toxicol . 2007;26:427–434
  29. Aydinoglu F , Yilmaz SN , Coskun B , Daglioglu N , Ogulener N . Effects of ethanol treatment on the neurogenic and endothelium-dependent relaxation of corpus cavernosum smooth muscle in the mouse . Pharmacol Rep . 2008;60:725–734
  30. Chew KK , Bremner A , Stuckey B , Earle C , Jamrozik K . Alcohol consumption and male erectile dysfunction: an unfounded reputation for risk? . J Sex Med . 2009;6:1386–1394
  31. Feldman HA , Johannes CB , Derby CA , et al.   Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts Male Aging Study . Prev Med . 2000;30:328–338
  32. Bacon CG , Mittleman MA , Kawachi I , Giovannucci E , Glasser DB , Rimm EB . A prospective study of risk factors for erectile dysfunction . J Urol . 2006;176:217–221
  33. Millett C , Wen LM , Rissel C , et al.   Smoking and erectile dysfunction: findings from a representative sample of Australian men . Tob Control . 2006;15:136–139
  34. Terai A , Ichioka K , Matsui Y , Yoshimura K . Association of lower urinary tract symptoms with erectile dysfunction in Japanese men . Urology . 2004;64:132–136
  35. Cho BL , Kim YS , Choi YS , et al.   Prevalence and risk factors for erectile dysfunction in primary care: results of a Korean study . Int J Impot Res . 2003;15:323–328
  36. Bai Q , Xu QQ , Jiang H , Zhang WL , Wang XH , Zhu JC . Prevalence and risk factors of erectile dysfunction in three cities of China: a community-based study . Asian J Androl . 2004;6:343–348
  37. Shaeer KZ , Osegbe DN , Siddiqui SH , Razzaque A , Glasser DB , Jaguste V . Prevalence of erectile dysfunction and its correlates among men attending primary care clinics in three countries: Pakistan, Egypt, and Nigeria . Int J Impot Res . 2003;15(Suppl 1):S8–S14
  38. Nicolosi A , Moreira ED , Shirai M , Bin Mohd Tambi MI , Glasser DB . Epidemiology of erectile dysfunction in four countries: cross-national study of the prevalence and correlates of erectile dysfunction . Urology . 2003;61:201–206
  39. Moreira ED , Lisboa Lôbo CF , Villa M , Nicolosi A , Glasser DB . Prevalence and correlates of erectile dysfunction in Salvador, northeastern Brazil: a population-based study . Int J Impot Res . 2002;14(Suppl 2):S3–S9
  40. Akkus E , Kadioglu A , Esen A , et al. , Turkish Erectile Dysfunction Prevalence Study Group    Prevalence and correlates of erectile dysfunction in Turkey: a population-based study . Eur Urol . 2002;41:298–304
  41. Mak R , De Backer G , Kornitzer M , De Meyer JM . Prevalence and correlates of erectile dysfunction in a population-based study in Belgium . Eur Urol . 2002;41:132–138
  42. Cheng JY , Ng EM , Chen RY , Ko JS . Alcohol consumption and erectile dysfunction: meta-analysis of population-based studies . Int J Impot Res . 2007;19:343–352
  43. O'Farrell TJ , Kleinke CL , Cutter HS . Sexual adjustment of male alcoholics: changes from before to after receiving alcoholism counseling with and without marital therapy . Addict Behav . 1998;23:419–425
  44. Mandell W , Miller CM . Male sexual dysfunction as related to alcohol consumption: a pilot study . Alcohol Clin Exp Res . 1983;7:65–69
  45. Snyder S , Karacan I . Effects of chronic alcoholism on nocturnal penile tumescence . Psychosom Med . 1981;43:423–429
  46. Lemere F , Smith JW . Alcohol-induced sexual impotence . Am J Psychiatry . 1973;130:212–213
  47. Leiblum SR , Rosen RC . Alcohol and human sexual response . In:  Powell DJ editors. Alcoholism and Sexual Dysfunction: Issues in Clinical Management . Binghampton, New York: Haworth Press; 1984;p. 1–16
  48. Esposito K , Giugliano F , Di Palo C , et al.   Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial . JAMA . 2004;291:2978–2984

 There are 2 CME questions based on this article

PII: S1879-5226(10)60037-1

doi:10.1016/S1879-5226(10)60037-1

Urological Science
Volume 21, Issue 4 , Pages 163-168, December 2010